Relation between Alzheimer’s Disease and Metabolic Syndrome

Does Alzheimer’s disease-related to metabolic syndrome?


Alzheimer’s disease is a kind of dementia in which there is a progressive loss in the function of the brain of a person leading to complete dysfunction. The patient becomes unable to comprehend and respond to everything around.

It affects the hippocampus which is an important part of our brain that controls our memory, thoughts, and other communication abilities. A person suffering from Alzheimer’s disease neither remembers anything related to his past life nor understands the present situations.

The structure of the brain of the patient is completely altered like shown in the figure below:

According to research published on ScienceDirect, almost 36 million people are suffering from Alzheimer’s disease worldwide. It is a major cause of death in older people. Although it occurs in the younger people too the ratio is too low as compared to the elder people. People above the age of 65 years are more likely to suffer from this condition. The number of patients is increasing day by day due to other related health issues.

Causes of Alzheimer’s disease


Health professionals are constantly trying to know the cause of Alzheimer’s disease. The exact cause is still unknown but many risk factors aid in the onset of this disease. Some of these factors are:

With the increase of age, the immune system of a person becomes unable to properly protect a person. This may cause them to fall prey to many deadly diseases. In older age, certain damage s caused to the different parts of the body of a function especially vascular tissues and brain resulting in the dysfunction of many organs.

Genetic disorder

Alzheimer’s disease is usually termed a genetic disorder. It is not true in all cases but a person can suffer from this disease if any closely related member of the family has suffered from it. The risk can be reduced by adopting a healthy lifestyle and adequate physical activities.

Metabolic syndrome

Metabolic syndrome is known to be an important cause of Alzheimer’s disease. There can be abnormal chemical processes in the body of the patient that affect the normal functioning of the brain. The loss of functions can cause dementia.

Among the metabolic syndrome, the impaired mitochondrial energy metabolism is the characteristic cause of Alzheimer’s disease. It affects the function of the neuron. There is not enough energy production to carry out the functioning of the organs.

How Dementia Is Caused Due to Metabolic Causes?

Dementia caused by metabolic syndrome like uncontrolled metabolic processes is reversible at the start of the onset. If the person does not seek medical assistance as early as possible the situation can become worse and permanent damage can occur.

Following are some of the metabolic causes that cause Alzheimer’s disease:

Hormone production

The unnecessary hormone production in the body of a person can cause Alzheimer’s disease. Recent researches published by NCBI have suggested that the increase in the estrogen level in the body of old-age women increases the risk of Alzheimer’s.

Presence of metabolites in the body

Increased levels of different metabolites including heavy metals like arsenic and lead in the body can cause the impairment of brain function. If no control preventions are done at an early stage, the Alzheimer’s disease caused is not possible to treat.

  Metabolic diseases

Many diseases caused by the uncontrolled metabolism of the cells like cancer and cardiovascular problems affect the functioning of the brain. They cause the conditions like dyslipidemia and hyperinsulinemia leading to permanent memory loss. The following picture depicts that how metabolic diseases lead to Alzheimer’s disease.

Vitamin deficiencies

Many vitamins are required in the body for preventing malnutrition in the body of people. If there is a vitamin deficiency in the body, loss of body functions may occur leading to Alzheimer’s disease.

All these conditions are very strongly related to the onset of Alzheimer’s disease in most cases. There is a need to prevent yourself from metabolic syndrome to reduce the risk of dementia.


Among the other causes of Alzheimer’s disease, metabolic syndrome is the leading cause. A person’s condition becomes terrible during this disease. Maintaining the proper lifestyle by proper daily exercise, diet, low consumption of alcohol, and adopting other lifesaving habits can prevent metabolic syndrome and dementia.

Does Metabolic syndrome cause Dementia?

Yes, it is one of the important causes of Dementia/Alzheimer’s disease.

Does unnecessary hormone production also contribute to Alzheimer’s disease?

Yes, the unnecessary hormone production in the body of a person can cause Alzheimer’s disease.